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NISCI (Nogo-A Inhibition in acute Spinal Cord Injury)
is a multicenter, multinational, placebo controlled phase-II study for the safety and preliminary efficacy of intrathecal anti-Nogo-A [NG101] in patients with acute cervical spinal cord injury.
The purpose of the NISCI trial is to test if an antibody therapy can improve motor function and quality of life of tetraplegic patients. A previous trial showed this treatment is safe and well accepted. This current trial has been approved by the National Ethics Committee and Ministry of Health for all participating trial sites.
Find NISCI under Clinical Trials.gov
IMI’s next Calls for proposals are currently under discussion and are expected for early 2020.
The list of topics under discussion is given below:
- Neurodegeneration and other neuroscience priorities
- Infection control including vaccines
- Big data, digital health, clinical trials and regulatory research
- Facilitating the translation of advanced therapies to patients in Europe
More >> here: https://www.imi.europa.eu/apply-funding/future-topics
Deadline 07.April 2020, funding 10-20 Mio €
The reliability and relevance of animal studies to support chemical safety assessment are subject to increasing scrutiny from a scientific perspective and raises broader societal concerns. To address these challenges, the European Commission has been supporting the development and application of animal-free approaches to toxicological profiling of chemicals in support of chemical safety assessment. However, significant challenges remain regarding the provision of viable animal-free solutions to address systemic health effects in humans potentially linked to chronic exposure to chemicals across a variety of regulated sectors. Consequently, further efforts are needed to progress on the development, validation and translation of scientifically sound methods that not only decrease the reliance on animal testing but which also deliver more relevant, reliable and cost-effective means to facilitate decision-making to support regulation, innovation and competitiveness.
open call for proposals >> here