BE-SAFE - Implementing a patient-centred and evidence-based intervention to reduce
BEnzodiazepine and sedative-hypnotic use to improve patient SAFEty and quality of care
Benzodiazepine and sedative hypnotics (BSHs) incur significant adverse effects and costs, especially in older adults.
Addressing BSH overuse in older adults is therefore an urgent priority to improve patient safety in Europe. However,
previous attempts did not lead to large-scale reduction in use.
The goal of BE-SAFE is to improve patient safety by addressing knowledge and practice gaps related to the reduction
of BSHs used for sleep difficulties in Europe.
Coordinated by Prof. Anne Spinewine, Université Catholique de Louvain, (BE), project management by tp21.
Duration: 5 years, starting 1 September 2022 - Total funding: approximately € 5.7 million.
eBRAIN-Health - Actionable Multilevel Health Data
Coordinated by Prof. Petra Ritter, CHARITE, project management by tp21.
Duration: 4 years, starting 1 July 2022 - Total funding: approximately € 13 million.
The project aims to develop a decentralized, data protection-compliant research platform capable of simulating some of the brain’s complex neurobiological phenomena. As part of the project, researchers will collate an array of different types of information, including data from PET and MRI scans, EEG tests, behavioral studies and lifestyle surveys, as well as clinical data from thousands of patients and healthy controls. These will be combined with biological information from knowledge databases and made available for research purposes. The resultant digital ‘brain twins’ will enable large numbers of researchers to conduct innovative research within a powerful digital infrastructure.
Thanks to its transparent analytical pipelines, the new research infrastructure will also help to promote reproducible research.
Furthermore, complex, personalized brain simulations which take into account large quantities of data may be able to provide a better understanding of the mechanisms underlying brain function and disorders. Virtual brain modeling may also improve diagnostics and disease prediction, in addition to enabling the optimization of treatment plans. The project consortium comprises 20 partners and operates in cooperation with EBRAINS AISBL, the coordinating entity of the EU-funded flagship ‘Human Brain Project’.
ENDOSCAPE will overcome a longstanding and major bottleneck in the field of gene delivery,
namely efficient, safe and cost-effective transfer of gene therapeutic products into the cytosol.
see Topics and Speakers
- Gene Therapy – Where We Stand Today
- Endosomal Escape – The Strategies
- Carriers of Endosomal Escape Enhancers and Genes
- Endosomal Escape – What Happens?
- GMP Production and Market
- Gene Therapy – Animal Experiments and Clinical Applications
- Poster sessions
- Christine Dufès, University of Strathclyde Glasgow
- Kazunori Kataoka, The University of Tokyo
- Fulvio Mavilio, Università degli Studi di Modena e Reggio Emilia
- Luigi Naldini, Università Vita-Salute San Raffaele Milano
- Jean-Philippe Pellois, Texas A&M University
- Pål Kristian Selbo, Oslo University Hospital
- Vladimir P. Torchilin, Northeastern Univerity Boston
- Jan van Hest, Eindhoven University of Technology
- Ernst Wagner, Ludwig-Maximilians-Universität München
- Inge Zuhorn, University Medical Center Groningen
The SYMPOSIUM is planned to be an onsite event at Berlin.
More details soon on the ENDOSCAPE website.
Please have a look at the >>ENDOSCAPE Video
The topic will be Recruitment in Clinical Trials.
ICTD 2022 will take place 17 May 2022 in Berlin, Langenbeck-Virchow-Haus.
Registration is mandatory. Details >> here.
Tech Day brings together teams of experts from across the European Patent Office to explore a technological theme of special significance.
The theme of Tech Day 2022 is technologies of transformation: those technologies developed in response to the most pressing global crises of our time with a view to sustaining planetary health - both human health and the health of our planet.
Please note that registration is required for this free event.
New European initiative will build a collaborative platform for data and sample sharing, to accelerate the discovery and validation of biomarkers for neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD).
- EPND will become a future European infrastructure, facilitating access to biological samples and data to accelerate biomarker discovery and validation and eventually support the development of therapeutics for neurodegenerative diseases.
For more please visit www.epnd.org
- The European Platform for Neurodegenerative Diseases (EPND) integrates existing initiatives to build, grow, and deliver a scalable and self-sustainable platform for storage and analysis of high-quality clinical samples and data collections.
- EPND is a public-private partnership funded by the Innovative Medicines Initiative (IMI), a Joint Undertaking between the EU and European pharmaceutical industries that supports projects at the vanguard of health research.
EPND will bring together 29 partners from the public and private sectors and will be managed by two public partners, University of Maastricht and University of Leicester, and two private partners, Gates Ventures and UCB Biopharma. EPND will leverage and connect existing European research infrastructures, including BBMRI, EATRIS, ELIXIR and EBRAINS.
22.-27. January 2022
The most important biomedical optics conference in the field
29 Nov - 01 Dec 2021
This event will provide essentials and timely information about global clinical trial disclosure, data transparency, data sharing for secondary research and updates on the EU Clinical Trial Information System (CTIS) and how Brexit is impacting the disclosure ecosystem.
- Strategic Aspects of Disclosure and Transparency Beyond Compliance
- UK Disclosure Requirements Updates’
- Patients’ Perspectives around Disclosure
- Considerations on Increased Transparency, Data Privacy and Data Sharing
- Disclosure Requirements in Medical Device Studies
- Non-Interventional studies
- Academia’s Challenges in Clinical Trial Disclosure – Bridging the Gap
- Global Collaboration Initiatives and the Benefits for Transparency & Disclosure
- Lay Summaries are coming!
- Public Demonstration of EU CTIS
- EU Clinical Trial Regulation: Joint Collaboration within Industry Organisation
European Patent Office online conference for patent search professionals, 6-8 October 2021.
>>Recorded sessions. The focus was on medical technologies, one of the fastest paced areas of innovation and patent filing in Europe. They accounted for over 14 000 applications at the EPO in 2020 – around 7% of all filings and an increase of 2.6% on 2019.
Research and Innovation Action
- researchers, healthcare professionals, cancer patients and survivors contributing to cancer research regularly interact with EOSC to store, share, access, analyse and process research data and other research digital objects from their own discipline, across disciplines and national borders;
- open and FAIR data are the new norm for research conducted under this mission area;
- EU-wide sharing of research data relevant to this area is shown to be a critical mechanism to facilitate cancer research across Member States and Associated Countries;
- contribute to guaranteeing safety of patients’ data while at the same time contributing to research advancement. Engaging with patients/survivors in the sharing, access and use of data;
- EOSC grows into a trusted research and innovation data space and service platform in Europe that supports the interdisciplinary community involved in this mission area;
- contribute to the Horizon Europe EOSC Partnership and other relevant partnerships related to cancer research.
The new Horizon Europe 2021-2022 work programs are now published.
First calls are open.
All work programs are available on the Funding and Tenders Portal under "Reference Documents".
tp21 supports application set-up and project management.
The Digital Europe Programme (DIGITAL) is a new EU funding programme focused on bringing digital technology to businesses, citizens and public administrations.
A planned overall budget of € 7.5 billion will support projects in five key capacity areas:
supercomputing | artificial intelligence | cybersecurity | advanced digital skills | ensuring a wide use of digital technologies across the economy, society, including through Digital Innovation Hubs.
How to get funding? More here
“Implementing an inclusive European Open Science Cloud”
Slides and Recordings available >> here
TVB-Cloud is a project of the European Open Science Cloud (EOSC).
The European Commission mobilises €123 million for research and innovation to combat the threat of variants.
Two calls are published
- Vaccines & therapeutic clinical trials to boost COVID-19 prevention and treatment
- Cohorts united against COVID-19 variants of concern.
tp21 supports application set-up and project management.
ERC starts with the first work programme under Horizon Europe, Europe’s new Framework Programme for Research and Innovation for 2021-2027.
ERC supports investigator-driven frontier research across all fields, on the basis of scientific excellence.
The call calendar, deadlines and the work programme for download >> here
Joint transnational call “Addressing adverse and beneficial effects of food ingredients and food processing on hypersensitivities to food.
The aim of this call is to address how food ingredients and food processing methods could favour or prevent the occurrence of food intolerances and allergies in society.
The publication of the work programme and the first calls is expected in April 2021.
Find more about the HORIZON Europe clusters and missions >> here.
The Virtual Brain Cloud project is partner in the European Open Science Cloud initiative.
Short video explaining the Virtual Brain Cloud - a GDPR compliant health data platform for the personalized prevention and treatment of dementia.
more >> here
The European Commission has decided to launch a €1 billion call for research and innovation projects that respond to the climate crisis and help protect Europe's unique ecosystems and biodiversity.
Find here details on the Horizon 2020-funded >> European Green Deal Call.
Achieving Gender Diversity
European Training Network G-VERSITY joins 8 leading European research groups from psychology, education, management, business administration, media and communication studies.
tp21 supports the MANIFESTO initiative:
MAXIMISING the accessibility of research results in the fight against Covid-19.
More details about >> MANIFESTO
Call for projects on low-carbon technologies and processes
deadlines in 2020 and 2021
see more << here
The ERA corona platform is one of the 10 priorities of the European Commission and national ministries agreed on the first ERAvsCorona action plan.
Answers on questions such as
- fulfillment of time / delivery date commitments
- documentation of working hours during home office
- project extension
- review meetings
- reimbursement of costs for cancelled event
More >> here
The 17 projects, short listed for funding, involve 136 research teams from across the EU and beyond will work on:
- Improving epidemiology and public health, including our preparedness and response to outbreaks
- Rapid point-of-care diagnostic tests
- New treatments
- Development of new vaccines
The recent escalation of restrictions related to the COVID-19 outbreak may hamper applicants’ ability to prepare and finalise high-quality proposals.
For this reason, for Horizon 2020 calls with original deadlines between now and 15 April, extensions will be applied. The precise new deadlines for each call and topic will be published on the call and topic pages on the Funding and Tenders Portal.
Horizon Europe will be launched on January 01 2021.
latest news see >> here
or on Twitter https://twitter.com/hashtag/HorizonEU
IMI call now published: Development of therapeutics and diagnostics combatting coronavirus infections
Scope: Considering that this is a newly-identified virus, the scope of this topic remains broad and must address at least one of the following objectives:
- development of antivirals as well as other types of therapeutics to address a rapid response to the current COVID-19 outbreak;
- development of therapeutics to address the current and/or future coronavirus outbreaks;
- development of diagnostics, ensuring rapid evaluation of candidates based on existing technologies;
- development of fast and reliable tools that go beyond the state of the art for detection of COVID-19 carriers and symptomatic individuals suspected of COVID-19 infection.
Preventive vaccines are specifically excluded from the scope of the Call.
- From EFPIA companies and IMI2 Associated Partners: to be defined based upon selected proposals
- From the IMI2 JU: EUR 45 000 000
- Submission deadline: 31 March 2020
For full details of the topic, including the budget breakdown and the General Conditions for the Call for proposals, click on the links above (which take you directly to the relevant page of the Participant Portal) or read the IMI2 - Call 21 Text.
>> Do not hesitate to contact tp21 to be the responsible management partner in your IMI proposal.
The Human Brain Project shows their work at the German Parliament Bundestag. The Virtual Brain is a central part of the exhibition.
Meet Dr. Petra Ritter during the opening event on Nov 27th . Dr. Ritter will also lead a guided tour through the exhibition on Nov 28.
Access to the exhibition is only possible after prior registration via the website.
This exhibition is in partnership with The Human Brain Project, and includes many beautiful exhibits about the brain. You don't want to miss it.
More information about the program >here<.
UK participation in Horizon 2020
The UK and the EU have agreed a flexible extension of the Article 50 period to 31 January 2020. During this period, the UK will remain a member of the EU with all the relevant rights and obligations. This means that UK organisations can continue to participate in Horizon 2020 as a Member State, and remain eligible to apply for Horizon 2020 funding. Read more about deal and no-deal scenarios to ensure continuity of funding here:
UKRO Brexit factsheet>> https://www.ukro.ac.uk/Documents/factsheet_brexit.pdf?pubdate=20191030
NISCI (Nogo-A Inhibition in acute Spinal Cord Injury)
is a multicenter, multinational, placebo controlled phase-II study for the safety and preliminary efficacy of intrathecal anti-Nogo-A [NG101] in patients with acute cervical spinal cord injury.
The purpose of the NISCI trial is to test if an antibody therapy can improve motor function and quality of life of tetraplegic patients. A previous trial showed this treatment is safe and well accepted. This current trial has been approved by the National Ethics Committee and Ministry of Health for all participating trial sites.
Find NISCI under Clinical Trials.gov
IMI’s next Calls for proposals are currently under discussion and are expected for early 2020.
The list of topics under discussion is given below:
- Neurodegeneration and other neuroscience priorities
- Infection control including vaccines
- Big data, digital health, clinical trials and regulatory research
- Facilitating the translation of advanced therapies to patients in Europe
More >> here: https://www.imi.europa.eu/apply-funding/future-topics
Deadline 07.April 2020, funding 10-20 Mio €
The reliability and relevance of animal studies to support chemical safety assessment are subject to increasing scrutiny from a scientific perspective and raises broader societal concerns. To address these challenges, the European Commission has been supporting the development and application of animal-free approaches to toxicological profiling of chemicals in support of chemical safety assessment. However, significant challenges remain regarding the provision of viable animal-free solutions to address systemic health effects in humans potentially linked to chronic exposure to chemicals across a variety of regulated sectors. Consequently, further efforts are needed to progress on the development, validation and translation of scientifically sound methods that not only decrease the reliance on animal testing but which also deliver more relevant, reliable and cost-effective means to facilitate decision-making to support regulation, innovation and competitiveness.
open call for proposals >> here
VirtualBrainCloud, coordinated by P. Ritter, CHARITE, a 15 Mio € EU project, started on Januar 1st 2019.
→ About VirtualBrainCloud
The annual worldwide cost of Alzheimer’s dementia was 777.81 billion Euro in 2015. This number will rise to 7.41 trillion Euro in 2050. Early diagnosis would save up to $7.9 trillion in medical and care costs by 2050 in the US alone. However, the emergent pathology is highly variable across people, necehighly variable across people, necessitating individualized diagnostics and interventions. The VirtualBrainCloud addresses this by bridging the gap between computational neuroscience and subcellular systems biology, integrating both research streams into a unifying computational model that supports personalized diagnostics and treatments in NDD. TheVirtualBrainCloud not only integrates existing software tools, it also merges the efforts of two big EU initiatives, namely The Virtual Brain large scale simulation platform of the EU Flagship Human Brain Project and IMI-EPAD initiative (European prevention of Alzheimer’s dementia consortium). VirtualBrainCloud will develop and validate a decision support system that provides access to high quality multi-disciplinary data for clinical practice. The result will be a cloud-based brain simulation platform to support personalized diagnostics and treatments in NDD. The EU PRACE (Partnership for Advanced Computing in Europe) initiative, will provide the required computing infrastructure. The VirtualBrainCloud will develop robust solutions for legal and ethical matters by interacting with EU projects such as European Open Science Cloud (EOSC), ‘cloud4health’, Alzheimer’s Europe patient organizations and ELIXIR, an organization that manages and safeguards EU research data. Our software developers have already produced highly successful brain simulation and clinical decision support tools. The resulting software will be a cloud based computational modeling system that is tailored to the individual, and bridges multiple scales to identify key mechanisms that predict NDD progression and serves as Precision Decision Support System.
The UK Intellectual Property Office has published a guide concerning the future of intellectual property (IP) rights and the recent Referendum decision on BREXIT.
What are possible consequences on trade marks, designs, patents, copyright and enforcement issues.
More >> here
The European Commission has published its proposal for Horizon Europe, an ambitious €100 billion research and innovation programme that will succeed Horizon 2020.
For the next long-term EU budget 2021-2027, the Commission is proposing €100 billion for research and innovation.
Ending the Pandemic Threat: A Grand Challenge for Universal Influenza Vaccine Development